320 PLACENTAL TRANSFER AND FETAL ELIMINATION OF MORPHINE
نویسندگان
چکیده
منابع مشابه
Placental transfer and fetal elimination of morphine-3-beta-glucuronide in the pregnant baboon.
The glucuronide metabolites of several widely used drugs are detected in fetal plasma after maternal drug administration. However, the disposition of these metabolites is poorly understood and clinical concerns have been raised about accumulation of active metabolites in the fetus. For this reason, morphine-3-beta-glucuronide (M3G), an active metabolite of morphine, was studied to provide quant...
متن کاملPlacental to fetal transfer of mercury and fetotoxicity.
Mercury vapor is known penetrate the placental barrier more easily than inorganic mercury. A relative amount of mercury accumulates in the fetus after exposure of pregnant animals to mercury vapor. Mercury concentration in fetal organs is much lower than that in maternal organs except the liver, and fetal liver shows significantly higher mercury concentrations than maternal liver. In fetal live...
متن کاملEffect of Aspirin Consumption during Pregnancy on Fetal and Placental Weights and Histomorphometric Changes of the Fetal Stomach in Rats
Background & Objective: Due to the relevant use of aspirin to relieve pain and common symptoms of gastric ulcer and possible malicious effects on fetus, this study investigates the histomorphologic effects of aspirin on the stomach tissue in rat embryos. Materials & Methods: In this experimental study, 30 pregnant female rats were randomly divided into six groups including control group wi...
متن کاملPlacental transfer and fetal metabolic effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery.
BACKGROUND Use of ephedrine in obstetric patients is associated with depression of fetal acid-base status. The authors hypothesized that the mechanism underlying this is transfer of ephedrine across the placenta and stimulation of metabolism in the fetus. METHODS A total of 104 women having elective Cesarean delivery under spinal anesthesia randomly received infusion of phenylephrine (100 mic...
متن کاملPlacental transfer and maternal and fetal hemodynamic effects of ketanserin in the pregnant ewe.
OBJECTIVE To determine placental transfer of ketanserin and to assess the effect of serotonin-2 receptor blockade by ketanserin on serotonin- and phenylephrine-induced vasoconstriction. STUDY DESIGN Five chronically instrumented pregnant ewes at 120 days gestation were injected with 20 mg ketanserin i.v., and fetal and maternal arterial samples were obtained at predetermined intervals to asse...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1981
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198104001-00331